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phenobarbital boosts toxicity of ifosfamide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of. CYP3A4 inducers may well enhance the metabolism of ifosfamide to its Lively alkylating metabolites.Phenobarbital is usually a barbituric acid spinoff for oral administration and occurs to be a white, odorless, a little bi